![]() Concomitantly, the tube lengthens and rotates, as it transforms from a short, occluded cylinder to a long, hollow conduit arranged in a three dimensional configuration of loops and coils.Įlucidating the mechanisms of digestive organ development has broad implications for many areas of biology and medicine. This PGT undergoes intricate patterning and differentiation events to enable the epithelial lining of the tube to assume the absorptive and secretory functions required of a gastrointestinal (GI) tract, while discrete segments bud off of the original structure to form accessory organs, including the pancreas and liver. The anatomical and physiological complexity of the vertebrate digestive system develops from a simple primitive gut tube (PGT). The unparalleled experimental versatility of frog embryos make them excellent, integrative models for studying digestive organ development across multiple disciplines. Additionally, we discuss recent studies of gut development in non-model frog species with unique feeding strategies, such as Lepidobatrachus laev is and Eleutherodactylouscoqui, which are beginning to provide glimpses of the evolutionary mechanisms that may generate morphological variation in the digestive tract. In this review, we highlight specific examples of how investigations using Xenopus laevis frog embryos have revealed insight into the molecular and cellular dynamics of digestive organ patterning and morphogenesis that would have been difficult to obtain in other animal models. Improved understanding of the complex molecular and cellular events that orchestrate digestive organ development is pertinent to many areas of biology and medicine, including the regeneration or replacement of diseased organs, the etiology of digestive organ birth defects, and the evolution of specialized features of digestive anatomy. ![]() Many aspects of digestive organ function are highly conserved among vertebrates, yet the final anatomical configuration of the gut varies widely between species, especially those with different diets. The digestive system comprises numerous cells, tissues and organs that are essential for the proper assimilation of nutrients and energy.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |